High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm labor
نویسندگان
چکیده
منابع مشابه
Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina.
BACKGROUND This study was designed to evaluate the plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in patients with unstable angina and investigate whether there is a relationship between these levels and unfavorable outcome. METHODS AND RESULTS The plasma TF and free TFPI antigen levels were determined in plasma samples taken from 51 patients with unstable angi...
متن کاملTissue factor, tissue factor pathway inhibitor and cytoadhesive molecules in patients with an acute coronary syndrome.
The tissue factor plays a crucial role in initiating blood coagulation after plaque rupture in patients with acute coronary syndrome. It is abundant in atherosclerotic plaques. Moreover, P-selectin, some cytokines, endotoxin and immune complexes can stimulate monocytes and induce the tissue factor expression on their surface. The aim of the study was to compare plasma levels of the tissue facto...
متن کاملLow plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.
Severe factor V (FV) deficiency is associated with mild to severe bleeding diathesis, but many patients with FV levels lower than 1% bleed less than anticipated. We used calibrated automated thrombography to screen patients with severe FV deficiency for protective procoagulant defects. Thrombin generation in FV-deficient plasma was only measurable at high tissue factor concentrations. Upon reco...
متن کاملCaveolae optimize tissue factor-Factor VIIa inhibitory activity of cell-surface-associated tissue factor pathway inhibitor.
TFPI (tissue factor pathway inhibitor) is an anticoagulant protein that prevents intravascular coagulation through inhibition of fXa (Factor Xa) and the TF (tissue factor)-fVIIa (Factor VIIa) complex. Localization of TFPI within caveolae enhances its anticoagulant activity. To define further how caveolae contribute to TFPI anticoagulant activity, CHO (Chinese-hamster ovary) cells were co-transf...
متن کاملTissue factor pathway inhibitor in paediatric patients with nephrotic syndrome.
BACKGROUND: Tissue factor pathway inhibitor is an endogenous protease inhibitor that regulates the initiation of the extrinsic coagulation pathway by producing factor Xa-mediated feedback inhibition of the tissue factor/factor VIIa (TF/VIIA) catalytic complex. OBJECTIVES: To evaluate plasma TFPI levels in paediatric patients with nephrotic syndrome and its correlation with disease activity. S...
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ژورنال
عنوان ژورنال: The Journal of Maternal-Fetal & Neonatal Medicine
سال: 2009
ISSN: 1476-7058,1476-4954
DOI: 10.3109/14767050902994770